Sunday, Dec 08, 2019
 
search SGN
SERVING SEATTLE AND THE PACIFIC NORTHWEST FOR 42 YEARS!

click to visit advertiser's website


Javascript DHTML Drop Down Menu Powered by dhtml-menu-builder.com

Last Weeks Edition
   
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
 
 
 
 
 
 
 
 
 
 




 

 
 

 

 

[Valid RSS]

click to go to advertisers website
to Section One | to Arts & Entertainment
posted Friday, May 15, 2015 - Volume 43 Issue 20
New HIV breakthrough: Implants can solve adherence problem
Section One
ALL STORIES
  next story
New HIV breakthrough: Implants can solve adherence problem

by Mike Andrew - SGN Staff writer

Scientists at Oak Crest Institute of Science in Pasadena say they have developed a subdermal implant that can deliver antiretroviral drugs. Their finding is published in the latest issue of Antimicrobial Agents and Chemotherapy.

The implant is said to be about the size of a matchstick, and can deliver a controlled and sustained release of anti-HIV drugs for up to 40 days with no adverse side effects. Tests have so far been done only with dogs, with human testing to follow.

'To our knowledge this is the first implant to be used for this purpose,' said Oak Crest founder and president Dr. Marc Baum.

'This novel device will revolutionize how we treat or prevent HIV/AIDS as it delivers powerful HIV-stopping drugs and eliminates one of the key obstacles in HIV/AIDS prevention - adherence to proper dosing regimens,' he added.

Although daily doses of antiretrovirals can help HIV-negative people to resist HIV infection - called pre-exposure prophylaxis, or PrEP therapy - adherence to the dosing regimen is problematic.

In fact, medical practitioners and scientists acknowledge that adherence is one of the main drawbacks in current HIV prevention and treatment strategies. An implant that automatically releases the correct dose of antiretrovirals could solve the problem.

'It's unfortunate, but patients do not always follow the dosing instructions as prescribed,' Baum said.

'In clinical trials erratic administration of drugs has led to highly variable efficacy outcomes. That's what peaked our interest in the possible use of a subdermal implant for the prevention of HIV.'

The use of subdermal implants for contraception began in the United States in 1993. A small flexible tube, measuring about 40mm in length, is inserted under the skin by a health care professional, typically the upper arm. After it is inserted it prevents pregnancy by releasing hormones that prevent ovaries from releasing eggs and by thickening cervical mucous.

'Our subdermal implant is used in the same manner as a contraceptive implant. It is easily inserted and removed and provides sustained release of the potent prodrug tenofovir alafenamide, which is roughly ten times more potent against HIV than tenofovir disoproxil fumarate, another tenofovir prodrug that has been shown to prevent sexually transmitted HIV when used as a pre-exposure prophylaxis,' Baum said.

'We are very pleased with the results of our preliminary studies and are working diligently to develop a subdermal implant for HIV prevention that will remain effective for a full 12 months.'

Tell a friend:

Share on Facebook  Share on Facebook

Post to MySpace!Share on MySpace!

    Share on Delicious

Share on StumbleUpon!

New HIV breakthrough: Implants can solve adherence problem
------------------------------
Sawant commands first District 3 candidate forum - Other candidates struggle to find their voice
------------------------------
Nepal hit with another quake
------------------------------
Emerald City Softball Association celebrates midseason with party
------------------------------
JESSE'S JOURNAL: Gay Envy
------------------------------
SEAMEC announces early endorsement of Herb Krohn for Port Commissioner
------------------------------
OUTSpoken welcomes Matthew Shepard's mother, Judy Shepard to the show
------------------------------
Donald J. Abshire - IN MEMORIAM
------------------------------
Academic student employees and UW agree on contract: Groundbreaking step toward an inclusive, equitable campus
------------------------------
Musicians win support for fair treatment - Seattle City Council to declare May 20 'Fair Trade Music Day'
------------------------------
Senator Patty Murray introduces Freedom from Discrimination in Credit Act
------------------------------
Chris Christie boozes it up - Embarrassed NJ Republicans pay state back for Christie's entertainment expenses
------------------------------
HHS to issue contraceptive guidelines in response to Patty Murray letter
------------------------------
Scotland most pro-Gay country in Europe, ILGA says
------------------------------
New HIV research partnership announced: UNC Chapel Hill and GlaxoSmithKline
------------------------------
AHF supports development of implant to deliver HIV drugs
------------------------------

------------------------------

------------------------------

------------------------------

------------------------------
BREAKING NEWS
------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

------------------------------

click to visit advertiser's website

click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
click to visit advertiser's website
Seattle Gay Blog post your own information on
the Seattle Gay Blog
 
 

gay news feeds gay news readers gay rss gay
http://sgn.org/rss.xml | what is RSS? | Add to Google use Google to set up your RSS feed
SGN Calendar For Mobile Phones http://sgn.org/rssCalendarMobile.xml
SGN Calendar http://sgn.org/rssCalendar.xml

Seattle Gay News - SGN
1605 12 Ave., Ste. 31
Seattle, WA 98122

Phone 206-324-4297
Fax 206-322-7188

email: sgn2@sgn.org
website suggestions: web@sgn.org

copyright Seattle Gay News 2015 - DigitalTeamWorks 2015

USA Gay News American News American Gay News USA American Gay News United States American Lesbian News USA American Lesbian News United States USA News
Pacific Northwest News in Seattle News in Washington State News