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to Section One | to Arts & Entertainment
posted Friday, January 11, 2013 - Volume 41 Issue 2
Spanish scientists announce 'therapeutic' HIV vaccine
Section One
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Spanish scientists announce 'therapeutic' HIV vaccine

by Mike Andrew - SGN Staff Writer

Spanish researchers say they have developed a therapeutic vaccine that can temporarily slow down the growth of HIV in infected patients.

The vaccine, based on immune cells exposed to HIV that had been inactivated with heat, was tested on a group of 36 HIV-positive people and the results were the best yet recorded for such a treatment, the team told Agence France Presse on January 3.

'What we did was give instructions to the immune system so it could learn to destroy the virus, which it does not do naturally,' said Felipe Garcia, one of the scientists on the research team at Barcelona University's Hospital Clinic.

The therapeutic vaccine treats an existing disease rather than preventing it, was safe, and led to a dramatic drop in the amount of HIV virus detected in some patients, said the study, published January 2 in Science Translational Medicine.

SHARP VIRAL LOAD DROP
After a 12-week trial, the HIV viral load dropped by more than 90% among 12 of the 22 patients who received the vaccine. Only one of the 11 patients who received a control injection (without the vaccine) experienced a similar result.

After 24 weeks, the vaccine's effectiveness began to decline, however, with only seven of the 20 remaining patients receiving the vaccine enjoying a similar 90% reduction in viral load. None of the control group of 10 patients experienced such a decline.

The vaccine lost its effectiveness entirely after a year, and the patients then had to return to their regular combination therapy of anti-retroviral drugs.

Researchers said the results were similar to those achieved with a single anti-retroviral drug, used to block the growth of HIV.

'It is the most solid demonstration in the scientific literature that a therapeutic vaccine is possible,' they said in a statement.

AN END TO DAILY MEDS?
During the time it remained effective, the vaccine allowed patients to live without taking multiple medicines on a daily basis, the team said.

'This investigation opens the path to additional studies with the final goal of achieving a functional cure - the control of HIV replication for long periods or an entire life without anti-retroviral treatment,' the researchers said in a statement.

'Although we still have not got a functional cure, the results published today open the possibility of achieving an optimal therapeutic vaccine, or a combination of strategies that includes a therapeutic vaccine, and could help to reach that goal,' they said.

The team said it took seven years to get to this point, and the researchers would now work on improving the vaccine and combining it with other therapeutic vaccines over the next three or four years.

According to the latest UN figures, the number of people infected by HIV worldwide rose to 34 million in 2011 from 33.5 million in 2010.

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